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Gabapentin Versus
Clonidine oral Premedication for Attenuation of pressor Response to
Laryngoscopy and Endotracheal Intubation
Suzan Faheim, M Hassanin , Ahmed Abdel Hafez
Anesthesia department, faculty of medicine, Tanta University, Egypt
Tanta Med. Sc. J 2008; 3(4):12-20
Article type: Original article
Background/Aim: We compared the effects of
gabapentin versus clonidine given 90 minutes before the start of
surgery on laryngoscopy, tracheal intubation in patients undergoing
elective hernia repair operations. Patients & Methods: Patients were
randomly divided into three double – blind groups, twenty patients
each, according to the premedication given to the patients 90
minutes before the start of surgery. Group I (gabapentin n= 20)
received oral gabapentin 600 mg capsule. Group II (clonidine n= 20)
received oral clonidine µg tablet. Group III (control n= 20)
received oral placebo. Results: Sedation, anxiolysis more in
clonidine than gabapentin and placebo. Heart rate at 1, 3, 5 and 10
minutes after tracheal intubation were significantly lower in
clonidine and gabapentin than placebo group. There was no
significant difference between group I and II. Blood pressure at 1,
3, 5 and 10 minutes after tracheal intubation were significantly
lower in both clonidine and gabapentin than placebo group and no
significant difference between group I and II, and postoperative
nausea and vomiting were found to be significantly lower in
clonidine and gabapentin groups when compared with placebo group (p<
0.005). Conclusion: Oral gabapentin is as effective as clonidine in
attenuation of pressor response to laryngoscopy and intubation.
ICID 881845 |