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The
Significance of Hyperuricemia in Gestational Hypertension and
Preeclampsia
Dina Gamal El-Deen El-Kholi
Department of Obstetrics and Gynecology, Faculty of Medicine, Tanta
University, Egypt.
Tanta Med. Sc. J 2008; 3(1):210-221
Article type: Original article
Background/Aim: Serum uric acid appears to have an independent link
with adverse perinatal outcome in gestational hypertension (GH) and
preeclampsia (PE). They acknowledged that additional verification of
their results is needed. We asked if hyperuricemia “HU” (serum uric
acid > 6 mg/dl), a common finding in hypertension of pregnancy might
also be an indicator of increased perinatal risk. The aim of this
work is to searching for the effect of HU on the perinatal outcome
in patients with GH and PE. Patients & Methods: A case-control study
was performed on 50 normal pregnant patients, 69 cases of GH and 106
PE admitted to hospital for delivery. They were assigned into 7
categories : 50 normal pregnancies, 38 cases of GH without HU, 31
cases of GH with HU 36 cases of mild PE without HU, 32 cases of mild
PE with HU, 18 cases of severe PE without HU and 20 cases of severe
PE with HU. All participants were primiparous with no known medical
complications. Serum uric acid was estimated on admission for
delivery in all categories. The frequency of preterm birth,
gestational age at delivery, infant birth weight, rate of admission
to the neonatal intensive care unit (NICU) and perinatal mortality
were reported in the seven categories. Results: Women with HU in the
last 6 categories were associated with shorter gestational age at
delivery, smaller birth weight, increased rate of admission to NICU
and perinatal mortality. HU increased the risk of these outcomes in
the presence or absence of proteinuria. Women with GH and HU had
similar and sometimes greater perinatal risk as women with severe PE
without HU. Those women with GH with HU had greater perinatal risk
than women with mild PE without HU. Those women with mild PE with HU
had greater perinatal risk than women with severe PE without HU. The
greatest risk was with severe PE and HU. HU should be considered in
the management of GH and PE as regard perinatal outcome. Conclusion:
There is no consensus of opinion about the correlation of serum uric
acid concentration and the severity of PE as regard blood pressure,
thrombocytopenia and level of liver enzymes. In the current study
severity of PE is not related to the serum uric acid concentration.
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