Volume 4 No. 2, April 2009

Potential Link of Apelin with Pathophysiology of Type II Diabetes Mellitus

Enas M. Elbendary⁽¹⁾ & Sohir Abdel Razq⁽²⁾.

Department of Physiology ⁽¹⁾ & General Medicine, ⁽²⁾ Tanta Faculty of Medicine, Tanta University, Egypt
Tanta Med. Sc. J 2009; 4(2):141-147

Abstract provided by Publisher

Aim: The objective of this study is to assess whether apelin or adiponectin or both are implicated in the pathophysiology of type II diabetes mellitus. Material & methods: This study was conducted on 30 diabetic males and 10 healthy as control group. The diabetic patients are classified into group I, is diabetic patients recently diagnosed and not yet receiving any treatment. Group II, 15 patients received treatment in the form of sulphonyl urea (Doaonil) one to three tablets (0.5-15mg) daily according to the patient's requirement since a mean of 10.5±3.02 years. Results: In untreated diabetic patients there is a significant increase in the fasting blood glucose level, HOMA-IR and body mass index on the other hand there is a significant lowering of apelin, adiponectin, fasting plasma insulin and HOMA-B compared to either normal control or diabetic treated patients. Conclusions: dysregulation of apelin and adiponectin might be involved in establishment of overt diabetes mellitus, and that apelin and or/ adiponectin might serve as a promising target for managing insulin resistance in type II diabetes.

ICID 893753