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Volume 4 No. 2, April 2009 |
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Endocrine and Metabolic Changes in Ovulatory Polycystic Ovary Syndrome Dina Gamal Eldeen Elkholi 1 & Halah Mohamed Nagy2
Department of Obstetrics & Gynecology1 &
Department
of
Clinical
pathology2, Faculty of Medicine, Tanta University
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| Abstract provided by Publisher |  |
Background/Aim: The endocrine and metabolic disorders had been
thoroughly investigated in classic polycystic syndrome C-PCOS) but
not fully studied in ovulatory polycystic ovary syndrome (OV-PCOS).
The aim of this work is to study the endocrine and metabolic changes
in ovulatory polycystic ovary syndrome (OV-PCOS). Patients &
Methods: a cross sectional study that included 69 patients with
OV-PCOS having regular menstrual pattern and hirsutism. Thirty women
with (C-PCOS) manifested by polycystic ovaries on sonograhy,
oligoovulation or anovulation and hyperandrogenism mainly hirsutism.
Other causes of hyperandrogenism were excluded. Thirty-one women of
normal weight, body mass index (BMI) ≤25kg/m2, normal ovulatory
cycles, regular menstrual pattern and no clinical evidence of
hyperandrogenism and normal ovarin morphology by ultrasonography
were selected as normal weight (NW) controls. In addition, 30 women
with ovulatory cycles, regular menstrual pattern, no clinical
evidence of hyperandrogenism and normal sonographic morphology of
the ovaries were matched for body weight with patients with C-PCOS.
They were considered as weight matched (WM) controls. For all
patients and controls estimation was performed for fasting glucose
and insulin and quantitative insulin-sensitivity check index (QUICKI),
LH, FSH, total testosterone (TT), androstenedione (A),
dehydroepiandsterone sulfate (DHEAS), cholesterol, high density
lipoproteins (HDL c), low density lipoprotein (LDLc) and
triglycerides. Results: BMI and waist-hip ratio (WHR) were
significantly (P<0.01) higher in C-PCOS and WM groups than the other
two groups. Insulin resistance (IR) : QUICKI ≤ 0.330 was detected in
28.98% of patients with OV-PCOS and 73.4% of patients of C-PCOS. LH
and FSH were normal in all groups but LH was significantly (P<0.01)
higher in C-PCOS. Dyslipidemia was found in 34.78% of patients with
OV-PCOS and in 46.66% of patients with C-PCOS. Conclusion: Both
OV-PCOS and C-PCOS have similar endocrine and metabolic
abnormalities that are more marked in the classic phenotype. This
may be attributed to the significantly higher BMI and WHR in C-PCOS
than in OV-PCOS.
ICID 893752