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Volume 4 No. 2, April 2009 |
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Adiponectin Correlation to Systemic Inflammatory Response with Cardiopulmonary Bypass in Coronary Artery Bypass Grafting Patients Ahmad A. Abdelhafez(1), Amal A. ahmed(2), Elsaied Almestekawy(3) & MA Attia(4)
Departments of Anesthesia (1), Histology(2),
Cardiothoracic Surgery(3) & Clinical Pathology(4),
Faculty of Medicine, Tanta University, Egypt
Background/Aim: Cardiopulmonary bypass is a well known cause of
systemic inflammatory response which is characterized by increase of
pro- inflammatory cytokines as IL6, IL8 and TNFα and has many
deleterious effects on the patients. Countless researches were done
to study the mechanisms, pathophysiology and management of the
inflammatory response to bypass. In this study we try to look to the
natural anti-inflammatory cytokines (adiponectin) and its
correlation to inflammatory response and the pro-inflammatory
cytokines hoping to be used as marker or to be a target for
management in the future. Patients & Methods: A prospective study of
25 patients undergoing elective Coronary revascularization with CPB
analysis of adiponectin, IL6, IL8 and TNFα were taken at the end of
bypass (t1), 12h postoperative (t2), 24h postoperative (t3), 48h
postoperative (t4). Results: We found significant increase in the
pro-inflammatory cytokines IL6, IL8 and TNFα intra-operative and
post-operative (p<0.05), while there was significant decrease in the
adiponectin level during all the time of the study (p<0.05), there
were significant negative correlation between adiponectin and
pro-inflammatory cytokines IL6, IL8 and TNFα during all the time of
the study (p<0.05). Conclusion: we may consider adiponectin as a
non-invasive predictor for the systemic inflammatory response to the
cardiopulmonary bypass as it is the marker represents
anti-inflammatory side of the response. |
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