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Esophageal Motility Disorders in Patients with Diabetes Mellitus
Fouad K. Harras,
Mervat A. Elkhatib, Mousa M. Alnaggar, Mahmoud Selim & Atef Taha.
Internal medicine Department, faculty of medicine, Tanta University,
Egypt.
Tanta Med. Sc. J 2008; 3(2):74-87
Article type: Original article
Background/Aim: The prevalence of gastrointestinal symptoms seems to
be increased in diabetics compared with general population. The aim
of this work is to study the esophageal motor abnormalities in
diabetic patients to determine whether esophageal motility disorders
are related to the symptoms and the clinical status of the patients.
Patients & Methods: The study was conducted on 120 diabetic patients
and 20 healthy control divided into-group I: 20 healthy controls,
group II: 60 type I diabetic patients, group III: 60 type 2 diabetic
patients. They were monitored by laboratory tests- Fundus
examination-Abdominal sonography–upper esophagogastric endoscopy -
esophageal manometry including lower esophageal sphincter study,
esophageal body study, and upper esophageal sphincter study. The
data was collected, statistically analyzed using computer program
SPSS version nine. Results: There was significant difference between
type I and 2 diabetics compared to controls regarding decrease in
lower esophageal resting pressure, decrease in peristalsis wave
percent, and decrease in proximal, distal body peristaltic
amplitude. None significant difference regarding lower esophageal
sphincter relaxation percent, residual pressure, proximal body
duration, distal body duration and upper esophageal sphincter
resting pressure were detected. There was significant difference
regarding decrease in peristaltic wave% non transmitted wave % and
proximal body amplitude in type I diabetics compared to type 2.
Conclusion: Diabetes per se is a significant risk factor for
increased incidence of esophageal motility dysfunction in the form
of decreased lower esophageal resting pressure, decreased body
peristalsis, increased non-transmitted wave percent. Increased
double-peak wave percent decreased proximal and distal body
amplitude. |