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Review of
Colorectal Cancer at King Abdulaziz University Hospital in Saudi
Arabia
Wael Tashkandi & Abdulrahman Ahmed Meccawy.
Surgical department, King Abdulaziz university hospital, Jeddah,
K.S.A
Tanta Med. Sc. J 2009; 4(3):83-92
ICID: 907313
Article type: Original articleIC™ Value: 4.54
| bstract provided by Publisher |
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Background/Aim: To detect outcomes of colorectal carcinoma patients
of different Duke stage (A, B, C & D) in patients who had undergone
different management options (Surgery, Chemotherapy and
Radiotherapy). Patients & Methods: Open label, national study for
163 colorectal carcinoma patients in Saudi Arabia. Enrolled patients
were observed to determine clinical symptoms and risk factors.
Investigations and Duke staging were done to determine best suitable
method of management (surgery, chemotherapy and radiotherapy). Tumor
sample was analyzed histopathologically to determine cell type and
grade. Finally prognosis of each case is reported. Results: 163
patients were enrolled; 58% of them were males, 31% were Saudi. 4
(3%) of patients were Duke A, 26 (20%) Duke B, 40 (30%) Duke C and
62 (47%) were Duke D. 25 (19%) were subjected to surgery only, 17
(13%) had chemotherapy only, 2 (2%) had radiotherapy only, 32 (25%)
had surgery, chemotherapy and radiotherapy, 26 (20%) had surgery and
chemotherapy while 28 (22%) had chemotherapy and radiotherapy. Duke
A, B and to a little extent C were more significantly associated
with Surgery alone or combined with other management options for
colorectal carcinoma (100% of Duke A cases, 80% of Duke B and 77% of
Duke C compared to only 39% of Duke D cases) (p value = 0.0002). On
the other hand, Chemotherapy and radiotherapy (alone or in
combination with surgery) were homogenously distributed in different
Duke Stages with no statistical difference (p value > 0.05).
Prognosis of Duke A, B and C was significantly much better than Duke
D (100% of Duke A cases become free after therapy, 70% of Duke B and
44% of Duke C compared to only 3% of Duke D cases) (p value =
0.0000). 74% of Duke D cases died compared to 26% of Duke C, 20% of
Duke B and 0% of Duke A. Prognosis was not significantly different
among different management options (free cases are 42% of patients
who undergone surgery, 27% of chemotherapy and 32% of radiotherapy)
(p value = 0.6078). Conclusion: The more advanced Duke stage of
colorectal carcinoma, the more probability to go for chemo or
radiotherapy (no surgery) and the worst prognosis (death, metastasis
and recurrence).
ICID 907313
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