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Efficacy
of Weight Reduction and Antioxidants on Liver Functions of Obese
Women with Fatty Liver
Eman Mohammed Saleh Ismail & Eman Omar Mohammed Al-Harthy
Department
of Nutrition & Food Science, Faculty of Home Economy & Art
Education, Jeddah, Saudi Arabia.
Tanta Med. Sc. J 2009; 4(3):94-104
ICID: 907314
Article type: Original articleIC™ Value: 4.54
| Abstract provided by Publisher |
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Aim: To identify the role of some antioxidants (vitamin C,
lycopene, whole grains) and weight reduction for (30) Obese Saudi
and non Saudi women with fatty liver and obesity. Patients &
Methods: 30 women suffering obesity, with body mass Index > 30 &
fatty liver by ultasonographic examination were included in the
study. They were divided into three groups; group I: was subjected
to a diet with high level of vitamin C 1500 mg and limited calorie
diet (Average 1230 Kcal); group II: was subjected to a diet with
high level of lycopene 50 mg and limited calorie diet (Average 1270
Kcal) & group III: was subjected to a diet with high level of whole
grains (with at least 30 gm fibers) and a diet limited in calorie
(Average 1240 Kcal). Measurements of liver enzymes, cholesterol,
triglycerides, levels of total antioxidants and glutathione
peroxides enzyme were done. Results: weight loss before and after
the diet was significantly difference, where losing weight was 7.2
kg in the group I, 10.6 kg in groupie & 11 kg in group III.
Significant differences with P <0.05 were also found between the
analysis of triglycerides and cholesterol before and after the diet.
The mean of triglycerides in the small sample was (0.3, 0.46 and
0.68 mmol/liter) respectively for the three groups with highest mean
for decrease was in group III. The mean decrease in cholesterol was
(1.08, 0.78 and 1.45 mmol/liter) respectively, with the highest mean
for decrease group III. Liver enzymes (AST, ALT) showed significant
differences in the three studied groups with higher reduction in
group III. Glutathione peroxides enzyme levels differences were
found with a confidence degree of 99% revealed to (19.58, 20.51 and
25.66 mmol/liter) respectively for the three groups, with highest
percentage of increase group III. After two months of diet,
ultrasound imaging showed improvement in liver condition, the rate
of recovery from high liver fats in group I was 20% (two ladies),
40% (four ladies) in group II & 70% in group III (seven ladies) was
registered. Conclusions: Balanced meals that contain whole grains,
high in fruit, vegetables & low fat most be used to maintain weight
and protect from Fatty Liver.
ICID 907314
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