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Role of Ghrelin and
Adiponectin in Pathogenesis of Polycystic Ovary Syndrome, Effect of
Metformin
Maessa M. El-Nahas1, Heba A. Mahmoud2, Manal
M. Abdulla3 & Manal El-Batch4
Departments of Physiology1, Pharmacology2, Gynecology3 &
Biochemistry4, Faculty of Medicine, Tanta University, Egypt
Tanta Med. Sc. J 2008; 3(3):38-47
Article type: Original article
Aim: this work has been designed to study the
role played by ghrelin and adiponectin in the pathogenesis of
polycystic ovary syndrome (PCOS) and to study the effect of
metformin which has insulin sensitizing properties on PCOS and on
ghrelin and adiponectin to connect metabolic changes with
reproductive changes. Subjects and methods: this study included ten
lean females (BMI <27 Kg/ m2) as control, another ten age matched
obese females (BMI >30 Kg/ m2 ) and twenty age matched obese females
(BMI > 30 Kg/ m2 ) patients with PCOS divided into two subgroups
under placebo or metformin 850mg three times daily for 6 months.
Assessed biochemical and hormonal parameters involved fasting plasma
glucose and insulin, HOMA-IR, lutenizing hormone (LH), follicle
stimulating hormone (FSH), sex hormone binding globulin (SHBG),
androstenedione, ghrelin and adiponectin. Results: both fasting
glucose and insulin are increased significantly in obese and obese
PCOS than lean subjects also HOMA-IR is significantly increased but
decreased significantly after metformin. LH, FSH and androstenedione
are significantly increased in obese and obese PCOS than lean
females while SHBG, ghrelin and adiponectin decreased significantly
in obese and obese PCOS than lean and significantly increased after
metformin treatment. Significant positive correlation between
ghrelin and adiponectin in both obese and obese PCOS before
treatment but significant negative correlation between ghrelin, BMI,
HOMA-IR and androstenedione also significant negative correlation
between adiponectin, BMI, HOMA-IR. Conclusion: our study suggested
that in obese and obese PCOS ghrelin and adiponectin were decreased
which suggest metabolic disorders and returned to normal after
correction of insulin resistance by metformin. Other studies are
suggested to determine effect of hypocaloric diet and physical
exercise.
ICID 870836
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