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Paraoxonase Gene 192
Polymorphism in Non Insulin Dependent Diabetes Mellitus in Saudi
Population
Zainy Banjr
Department of Clinical Biochemistry,
Faculty of Medicine,
King Abdul-Aziz
University, Jeddah, Kingdom of Saudia Arabia
Tanta Med. Sc. J 2008; 3(3):30-37
Article type: Original article
Aim: We investigated the effect of PON-1 192
polymorphisms on serum PON1 activity and lipid profiles in 62 non
insulin dependent diabetes mellitus (NIDDM) subjects and 69 healthy
controls. Patients & Methods: Polymerase chain reaction–based
restriction fragment was used to determine PON 192 gene
polymorphism. PON activity was measured by spectrophotometric assay.
Serum lipid was measured enzymetically. Results: Fasting blood
sugar, Total cholesterol, triglycerides, LDL serum level were
significantly higher in patient than control. HDL and APOA-1 were
low in control than diabetic patients. No significant deference was
found in distribution of PON-1 192 polymorphism (QQ, RR and QR)
between patients and control subjects. PON-1 192 enzyme activity was
significant lower in diabetics than in control subjects. PON-1 192
RR homozygote had significantly low PON-1 192 activity than QQ and
QR genotypes among the NIDDM populations (p<0.0001). Conclusion: our
results suggest that the paraoxonase activities are affected by PON1
genetic variability in NIDDM patients and controls.
ICID 870835 |