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Effect
of Commiphora Mukul Extract on Pituitary Thyroid Axis in Rats
SSahar A.Elsawy1, Maessa M. El-Nahas1, Mohamed
M. Shebl1 & Wafaa M. Ebrahim2
Departments of Physiology1 and Biochemistry2,
Faculty of Medicine, Tanta University, Egypt
Tanta Med. Sc. J 2008; 3(3):140-147
Article type: Original article
Aim: Is to study the effect of Commiphora mukul (CM) extract on
pituitary thyroid axis in rats. Materials & Methods: Twenty four
adult male albino rats were used in this study divided into four
groups equally {control, CM group (orally administered in a dose of
0.2 g/Kg B.w/d of CM extract), hypothyroid group (hypothyroidism was
induced by adding thiouracil to the drinking water at concentration
of 0.03%) and hypothyroid plus CM group}. Result: Oral
administration of CM extract either in normal or hypothyroid rats,
produced significant increase of triiodothyronine (T3), thyroxin
(T4), T3 / T4 ratio and activity of peroxidase and proteases
enzymes. It also produced significant decrease in thyroid
stimulating hormone (TSH), cholesterol and hepatic lipid
peroxidation (LPO) when these results are compared to those of
control, or hypothyroid group, with the exception of hepatic LPO,
which is insignificantly changed after oral administration of CM in
hypothyroid rats, as compared to hypothyroid group. Conclusion:
Thyroid-stimulating effect of CM is different from that TSH and
probably not mediated through the pituitary, it acts directly on
thyroid through increase the activity of peroxidase and proteases
enzymes enhance T3 more than T4 through decrease in lipid
peroxidation in the liver.
ICID 885218
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