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Lipid Profile and
Paraoxonase Enzyme Activity in Obese Saudi Population
Zainy Banjr
Department of Clinical Biochemistry,
Faculty of Medicine, King Abdul-Aziz University, Jeddah, Kingdom of
Saudi Arabia
Tanta Med. Sc. J 2008; 3(3):109-116
Article type: Original article
Aim: It is an investigation of the distribution
PON-1 192 polymorphisms and activity and lipid profiles in 71 obese
Saudi patients and 69 healthy controls. Patients & Methods:
Polymerase chain reaction–based restriction fragment was used to
determine PON-1 192 gene polymorphism. PON activity was measured by
spectrophotometric assay. Serum lipid was measured enzymetically.
Results: Fasting blood sugar was normal. Total cholesterol,
triglycerides, LDL serum level were significantly higher in patient
than control meanwhile HDL and APOA-1 were significantly low in
patients. No significant deference was found in distribution of
PON-1 192 polymorphism (QQ, RR and QR) between patients and control
subjects. PON-1 192 enzyme activity was significant lower in
diabetics than in control subjects. PON-1 192 RR homozygote had
significantly low PON-1 192 activity than QQ and QR genotypes among
the NIDDM populations (p<0.0001). Conclusion: our results suggest
that the paraoxonase activities are affected by PON1 genetic
variability in obese patients and controls.
ICID 874412 |