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Volume 4 No. 1, January 2009 |
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Intraoperative Esmolol
or Lidocaine Infusion Spare Postoperative Opioid Requirement in
Patients Undergoing Laparoscopic Cholecystectomy Department of Anesthesia & intensive care, Faculty of medicine, Tanta University, Egypt
Background/aim: This randomized, double blind, prospective study was
undertaken to evaluate the effect of intraoperative infusion of
esmolol or lidocaine on sparing postoperative opioid requirement and
the incidence of postoperative nausea and vomiting (PONV) in
patients undergoing laparoscopic cholecystectomy. Patients &
methods: 75 patients (ASA physical status I) who underwent elective
laparoscopic cholecystectomy were enrolled in this study; they were
randomly divided into 3 double blind group, 25 patients each. Group
I (esmolol group): received esmolol continuous 10ug.kg-1.min-1 until
the end of surgery. Group II (lidocaine group): received lidocaine
continuous infusion 2 mg.kg-1.h-1 until the end of surgery. Group
III (control group): received normal saline 0.9% infusion until the
end of surgery. General anesthesia was standardized in all three
groups. Patients were evaluated for postoperative pain,
postoperative opioid enquiry, PONV, ondansetron enquiry and time
till eligibility for discharge from post anesthesia care unit
(PACU). Results: The number of patients experienced pain and
required postoperative opioid were less in group I and II patients
than group III. The number of patients experienced PONV and required
ondansetron were less in group I and II than group III. The group I
and II patients were faster discharged from post anesthesia care
unit( PACU ) than group III patients but there was no difference
between group I & II as regard pain or opioid enquiry ,PONV ,or stay
in (PACU). Conclusion: intraoperative esmolol or lidocaine infusion
spare postoperative opioid requirement with fewer incidences of
postoperative nausea and vomiting (PONV) and rapid readiness for
discharge from PACU in patients scheduled for laparoscopic
cholecystectomy.
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