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Volume 4 No. 1, January 2009 |
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Dexmedetomidine versus
Sufentanil Premedication for Blunting the Increase in Intraocular
Pressure and Hemodynamic Response during Rapid-Sequence Induction
Department of Anesthesia, Faculty of medicine, Tanat University,
minofeyia university, Egypt
Background/aim: this randomized, double-blind, prospective study
was undertaken to compare the effect of dexmedetomidine versus
sufentanil premedication on the intraocular pressure (IOP) and
hemodynamic response to larnygoscopy and tracheal intubation using
succinylecholine as a neuromuscular block for rapid sequence
induction. Patients & methods: 90 patients (ASA physical status I)
who underwent elective non ophthalmic surgeries were randomly
divided into three double-blind groups, 30 patients each, according
to the premedication given just before induction of anesthesia:
Group I (sufentanil group n=30): received sufentanil 0.05ug.kg-1 I v
infusion over 10 minutes. Group II (dexmedetomidine group n=30):
received dexmedetomidine 0.6 ug.kg-1 I v infusion over 10 minutes.
Group III (placebo group n=30): received normal saline 0.9% Iv
infusion over 10 minutes. Anesthesia management of all patients was
standardized. Intraocular pressures , HR, MAP were measured at the
following period A0 (before the start of premedication ), A1(
immediate after completion of premedication), A2(immediate before
succinylcholine injection), A3( immediate after succinylcholine
fasciculation),A4(immediate after tracheal intubation), A5( 5
minutes after tracheal intubation ), and A6 (10 minutes after
tracheal intubation). Results: intraocular pressure (IOP) , heart
rate(HR ), mean arterial pressure(MAP) at the following times
A1,A2,A3,A4,A5 were significantly lower in group I (sufentanil
group) and group II (dexmedetomidine group )than group III(placebo
group ),there was no significant difference between group I and II.
Conclusion: dexmedetomidine premedication is as effective as
sufentanil for blunting the increase of the IOP and hemodynamic
response to laryngoscopy and intubation using succinylcholine as a
neuromuscular block for rapid sequence induction. |
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