Volume 4 No. 1, January 2009

Hemodynamic Effect of Exendin-4 and Its Putative Underlying Mechanism on Anaesthetized Rats
Maessa M. El-Nahas ⁽¹⁾, Enas M. Elbendary⁽¹⁾ & Mahmoud H. Elodemi⁽²⁾

Departments of Physiology, Faculty of Medicine, Tanta University⁽¹⁾  & Department of Pharmacology, Faculty of Medicine, Menoufyia University⁽²⁾, Egypt
Tanta Med. Sc. J 2009; 4(1):136-144

Abstract provided by Publisher

Aim: The aim of the present study is to investigate the hemodynamic effect of exendin-4 (Ex-4) and its underlying mechanism. Material and Methods: six groups of male albino rats (6 each), group I: injected I.V with Ex-4 in a bolus dose of 250 ng/kg, group II: injected I.V with propranolol in a dose of 1 mg/kg 15 min before Ex-4, group III: injected with Propranolol in the same dose and phentolamine in a dose of 1 mg/kg. 15 min before IV injection of Ex-4, group IV: medullary Denervation was done before IV injection of Ex-4, group V: atropine in a dose of I mg/kg I.V. 15 min before Ex-4, group VI: L-NAME IV injected in a dose of 3 ng/kg 15 min before Ex-4 injection. Heart rate, mean arterial pressure, hindlimb, mesenteric and renal flow and resistance were recorded. Results: IV injection of Ex-4 shows significant increase in heart rate, mean arterial pressure and hindlimb flow while the mesenteric flow significantly decreased and this action is abolished significantly after injection of propranolol and phentolamine also after medullary Denervation while the increase in hind limb flow decreased insignificantly after propranolol and L-NAME and the pressor action over mesenteric flow increased significantly. Conclusion: It can be concluded that Ex-4 has cardiovascular effects some of which include sympathoadrenal activation and others may be through GLP-1 receptor dependent action.

ICID 887626