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Volume 4 No. 1, January 2009 |
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Relation between Ghrelin and Pituitary Gonadal Axis in Female Rats Enas M. El-Bendary(1) & Nagwa E. Aglan(2) Departments of Physiology(1) and Obstetrics & Gynecology(2), Tanta faculty of Medicine, Tanta Univesity, Egypt
Tanta Med. Sc. J 2009; 4(1):110-116
Aim: The aim of the present study is to investigate the relation
between ghrelin and pituitary gonadal axis in female rats. Material
& Methods: Four groups of female rats (10 each) group I sham
ovariectomized rats, group II sham ovariectomized estrogen treated,
group III ovariectomized group, group IV ovariectomized estrogen
treated group. Body weight will be measured from all animals; blood
samples were taken at the end of experimental period (4 weeks) to
measure ghrelin, insulin like growth factor-1(IGF-1), estrogen,
progesteron, FSH and LH. Results: Ovariectomy causes significantly
decrease in ghrelin, FSH and LH, and significant increase in
estrogen and progesterone. Estrogen given to sham operated groups
causes only significant decrease ghrelin, FSH and LH. Estrogen
administered to ovariectomized rats causes significant reduction in
ghrelin, IGF-1, FSH, LH and body weight; also it causes significant
increase in estrogen and progesterone. Ghrelin is positively
correlated with FSH, LH, IGF-1 and body weight and negatively
correlated with estrogen and progesterone. Conclusion: It can be
concluded that ghrelin hormone is affected by activity of pituitary
gonadal axis in female rats.
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